Publicación:
Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain
Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain
| dc.contributor.author | Pichiule P. | es_PE |
| dc.contributor.author | Chávez J.C. | es_PE |
| dc.contributor.author | Boero J. | es_PE |
| dc.contributor.author | Arregui A. | es_PE |
| dc.date.accessioned | 2024-05-30T23:13:38Z | |
| dc.date.available | 2024-05-30T23:13:38Z | |
| dc.date.issued | 1996 | |
| dc.description | This work was supported in part by a grant from the Consejo Nacional de Ciencia y Tecnologfa (CONCYTEC) of Perti. (+)-MK-801 was generously supplied by Dr. Leslie Iversen (Merck, Sharpe and Dohme, UK). | |
| dc.description.abstract | This study examined [3H]MK-801 binding to the N-methyl-D-aspartate (NMDA) receptor in membranes prepared from cerebral cortex, hippocampus and corpus striatum of 3 week old rats exposed to 10 weeks of intermittent hypobaric hypoxia (4300 m; 450 Torr) and compared results wiLh those of normoxic controls. The cortex, hippocampus and striatum of hypoxic animals had a 36, 35 and 31% reduction in binding sites (Bmax) and a 29, 32 and 17% decrease (reflecting increased affinity) in the dissociation constant (Kd) when compared to controls. In the cerebral cortex, both glutamate (100 #M) and glycine (10 #M) enhanced [3H]MK-801 binding by two to 3- fold: Coagonist glutamate, however, had a higher ECs0 (0.44 #M) in the hypoxic cortical membranes when compared to controls (0.28 #M). No significant differences were found in the ECs0 of glycine. The results show that the NMDA receptor is altered in several brain regions of rats developing in a hypoxic environment. | en |
| dc.description.sponsorship | Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec | |
| dc.identifier.doi | https://doi.org/10.1016/S0304-3940(96)13113-X | |
| dc.identifier.scopus | 2-s2.0-0030296304 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12390/785 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | en |
| dc.relation.ispartof | Neuroscience Letters | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | n methyl dextro aspartic acid receptor blocking agent | |
| dc.subject | dizocilpine | es_PE |
| dc.subject | glutamic acid | es_PE |
| dc.subject | glycine | es_PE |
| dc.subject | n methyl dextro aspartic acid receptor | es_PE |
| dc.subject | animal experiment | es_PE |
| dc.subject | animal model | es_PE |
| dc.subject | animal tissue | es_PE |
| dc.title | Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain | |
| dc.type | info:eu-repo/semantics/article | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# |