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Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice

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dc.contributor.author Rubio, JL es_PE
dc.contributor.author Qiong, W es_PE
dc.contributor.author Liu, XM es_PE
dc.contributor.author Jiang, Z es_PE
dc.contributor.author Dang, HX es_PE
dc.contributor.author Chen, SL es_PE
dc.contributor.author Gonzales, GF es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2011
dc.description National Nature Science Foundation of China, NSFC in 2004 (30472016/C03020701); International Technologic Collaboration Project, grant no. 2006DFA21740; Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2005.
dc.description.abstract The present study aims to test two different doses of aqueous extract of black maca on learning and memory in ovariectomized (OVX) mice and their relation with malonalehyde (MDA), acetylcholinesterase (Ache) and monoamine oxidase (MAO) brain levels. Female mice were divided into five groups: (i) naive (control), (ii) sham, (iii) OVX mice and OVX mice treated with (iv) 0.50 g kg-1 and (v) 2.00 g kg-1 blackmaca.Mice were orally treated with distilled water or blackmaca during 35 days starting 7 days after surgery. Memory and learning were assessed using the water Morris maze (from day 23-27) and the step-down avoidance test (days 34 and 35). At the end of each treatment, mice were sacrificed by decapitation and brains were dissected out for MDA, Ache andMAO determinations. Black maca (0.5 and 2.0 g/kg) increased step-down latency when compared to OVX control mice. Black maca decreased MDA and Ache levels in OVX mice; whereas, no differences were observed in MAO levels. Finally, black maca improved experimental memory impairment induced by ovariectomy, due in part, by its antioxidant and Ache inhibitory activities.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.1093/ecam/nen063
dc.identifier.isi 293405400001
dc.identifier.uri https://hdl.handle.net/20.500.12390/1227
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartof Evidence-Based Complementary and Alternative Medicine
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Trastornos de la Memoria
dc.subject Experimentación Animal es_PE
dc.subject Ovariectomía es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.11
dc.title Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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