Publicación:
Ultrasound-assisted encapsulation of sacha inchi (Plukenetia volubilis Linneo.) oil in alginate-chitosan nanoparticles

dc.contributor.author Elgegren M. es_PE
dc.contributor.author Kim S. es_PE
dc.contributor.author Cordova D. es_PE
dc.contributor.author Silva C. es_PE
dc.contributor.author Noro J. es_PE
dc.contributor.author Cavaco-Paulo A. es_PE
dc.contributor.author Nakamatsu J. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2019
dc.description.abstract Sacha inchi oil is rich in essential and non-essential fatty acids and other types of bioactive agents like tocopherols and polyphenolic compounds, which are very well-known antioxidants. In this study, the encapsulation of sacha inchi oil in alginate (AL) and chitosan (CS) nanoparticles was achieved with the assistance of high-intensity ultrasound. Nanoemulsion is the most effective delivery and high stability system for lipophilic bioactive agents. Chitosan and surfactant concentrations were varied to study their effect on particle formulations. Size, zeta-potential, polydispersity, and stability of particles were determined in time to optimize the preparation conditions. Sacha inchi oil encapsulated in AL-CS nanoparticles showed a higher loading efficiency and stability for short and long periods compared with other vegetable oils such as olive and soybean. Also, because of the types of tocopherols present in sacha inchi oil (? - and ?-tocopherols), a much higher antioxidant activity (95% of radical reduction in 15 min) was found in comparison with nanocapsules with olive oil, which contain ?-tocopherols. The particles showed high efficiency of protein loading at high concentration of bovine serum albumin (BSA) and a low rate of leaching profiles in various testing media like simulated gastric and intestinal fluids with/without enzymes, that is, pepsin 0.1% (w/v) and pancreatin 0.1% (w/v), respectively. © 2019 by the authors.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.3390/polym11081245
dc.identifier.scopus 2-s2.0-85073899609
dc.identifier.uri https://hdl.handle.net/20.500.12390/2748
dc.language.iso eng
dc.publisher MDPI AG
dc.relation.ispartof Polymers
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Tocopherols
dc.subject Antioxidant es_PE
dc.subject Nanoemulsion es_PE
dc.subject Nile red es_PE
dc.subject Protein loading es_PE
dc.subject Sacha inchi es_PE
dc.subject.ocde http://purl.org/pe-repo/ocde/ford#2.10.01
dc.title Ultrasound-assisted encapsulation of sacha inchi (Plukenetia volubilis Linneo.) oil in alginate-chitosan nanoparticles
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
Archivos